Researchers from Chiba University in Japan have provided a scientific explanation for how psychological stress contributes to the return of rheumatoid arthritis symptoms, even after patient improvement. The university confirmed that exposure to stress triggers the body to release substances that increase inflammation, leading to joint swelling and symptom recurrence.
The researchers explained that this response activates the sympathetic nervous system, which helps the body cope with stress-inducing situations. It also stimulates a type of fat known as "brown fat," whose primary function is heat production. This activation leads to the secretion of a protein called "Interleukin-6," which is involved in regulating the immune response and may contribute to increased inflammation.
It was noted that this protein stimulates cells in the tissues surrounding the joints to release chemical signals that attract a type of white blood cell known as "neutrophils," which contribute to the occurrence and worsening of inflammation. The results showed that reducing the activity of certain receptors that help attract these inflammatory cells led to a decrease in arthritis inflammation.
For his part, researchers reported that examining patient data showed that the relationship between psychological stress and disease activity was weaker among those carrying a specific genetic variation. The results highlight the importance of managing daily stress and caring for mental rest among patients with chronic inflammatory diseases, alongside adhering to treatment and medical follow-up.
Source: Syrian Arab News Agency (SANA)
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